报告题目：Physical approaches to Nano-Bio-Med Challenges
报告人：Danny Porath
时间：9月1日星期二上午 10:00
地点：延长校区平板显示中心会议室
报告人简历：Danny Porath is professor of Chemistry, Etta and Paul Schankerman Chair of Molecular Biomedicine. He is the member of the Chemistry Institute Strategic Committee in 2013. He is the evaluator for Center for Nanoscience and Nanotechnology of Chinese Academy of Sciences in 2014. His group uses bio-templated systems for nanoelectronics applications. In recent years their research has strongly deviated to addressing biological and medical challenges using physical tools and approaches.
报告内容：In our research we address several topics within the scope of Nano-Biology and Nano-Medicine. We investigate translocation of DNA through nanopores towards developing methods for rapid DNA sequencing or investigating the interaction of the translocated DNA with proteins. We use solid state nanopores prepared by TEM drilling in SiN membrane. In one study we formed hybrid SP1 protein-solid-state nanopores, that enable to reduce the DNA translocation speed and dictate linear translocation of the DNA. In a parallel study, we investigate the SP1 protein as a nonapore in a lipid membrane. The research is conducted by my group in collaboration with the group of Oded Shoseyov. In another research we monitored in-vitro a critical stage in the life cycle of HIV using atomic force microscopy at the single molecule level. In yet another research we develop a method for ultra-sensitive macromolecules detection, e.g., cancer biomarkers. Measurement and detection of biomarkers provides essential information that allows prognosis and management of diseases. Our method does not involve amplification steps, used in other methods, and is performed at the single molecule level. It is based on binding of chemically treated nanoparticles to macromolecules, proteins or biomarkers and their characterization by electron microscopy imaging. The latter two projects are conducted by my group in collaboration with the group of Assaf Friedler and other groups.
